Key result
The Krogh tissue model predicted a biphasic relationship between O2 delivery and uptake for all forms of hypoxia, but required a postulated 30% peripheral O2 shunt to match experimental data.
Population
Krogh tissue cylinder model (theoretical computational model)
Design
Preclinical
Authors
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Questions Krogh model validity for hypoxic O2 delivery without shunting; challenges homogeneity assumptions and leaves open advanced tissue oxygenation models.
The classic Krogh tissue cylinder model fails to fully predict tissue O2 supply dependency without postulating a functional peripheral O2 shunt, highlighting limitations in its assumption of tissue homogeneity.
Schumacker et al. (1989) studied Hypoxia. Reduction in O2 delivery (anemic, hypoxic, or stagnant hypoxia) was evaluated on Relationship between tissue O2 supply (QO2) and uptake (VO2). The Krogh tissue model predicted a biphasic relationship between O2 delivery and uptake for all forms of hypoxia, but required a postulated 30% peripheral O2 shunt to match experimental data.
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