Key result
Neutralization of the Mahoney strain of poliovirus with monospecific antibodies in vitro led to progressive serological variation and resistance to up to five different antibodies.
Population
Poliovirus Mahoney strain in monkey kidney (MS) cells
Design
Preclinical
Authors
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Antigenic escape under antibody pressure merits monitoring in polio research; leaves open relevance to human vaccines or infection.
Poliovirus undergoes progressive antigenic variation when subjected to selective pressure from multiple monospecific antibodies in vitro.
Urasawa et al. (1977) studied Poliovirus. Neutralization with monospecific antibodies was evaluated on Antigenic variation and resistance. Neutralization of the Mahoney strain of poliovirus with monospecific antibodies in vitro led to progressive serological variation and resistance to up to five different antibodies.
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