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June 23, 2021Veterinary WorldOpen Access

Malignant cases of foot-and-mouth disease in buffalo calves consistently exhibited signs of dysautonomia and histopathological evidence of neurodegeneration, which were absent in recovered calves.

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Why the study?

Signs of dysautonomia were frequently observed in calves dying during foot-and-mouth disease outbreaks, prompting an investigation into central nervous system features in malignant cases while excluding concurrent infections.

Population

335 FMDV-infected buffalo calves aged 1-22 months in Egypt

Comparison

134 calves that died (malignant group) vs 201 calves that recovered

Design

Observational cohort study

Follow-up

Until recovery or death

Key result

Malignant cases of foot-and-mouth disease in buffalo calves consistently exhibited signs of dysautonomia and histopathological evidence of neurodegeneration, which were absent in recovered calves.

Authors

YBYasmin BayoumiNSNader M. SobhyAMAbdelkarem Morsi

Discussion

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Overview

Hypothesis-generating link between neurodegeneration and fatal FMD in calves; prospective studies needed before clinical adoption.

Study Design

Type

Observational (n=335)

Multicenter

Yes

PICO

P
Population
335 FMDV-infected buffalo calves aged 1-22 months from six farms in Egypt, followed until recovery or death to observe clinical and histopathological features of dysautonomia.
E
Exposure / Comparator
Malignant FMDV infection vs Recovered FMDV-infected calves
O
Primary Outcome
Signs of dysautonomia (e.g., cardiac arrhythmias, wide fluctuation in body temperature)

Main Result

Absolute Event Rate: 100% vs 0%

Limitations

  • Lack of immunohistochemistry facilities to conclusively prove neurotropism by localizing FMDV antigen in nervous tissue.
  • Further studies are required to establish a definitive causal association between neurodegeneration and FMDV infection.

Cite This Study

Bayoumi et al. (2021) conducted an observational in Foot-and-mouth disease (FMD) (n=335). Malignant FMDV infection vs. Recovered FMDV-infected calves was evaluated on Signs of dysautonomia (e.g., cardiac arrhythmias, wide fluctuation in body temperature). Malignant cases of foot-and-mouth disease in buffalo calves consistently exhibited signs of dysautonomia and histopathological evidence of neurodegeneration, which were absent in recovered calves.

synapsesocial.com/papers/6a92af85b1fb2e37bf1f65b6https://doi.org/10.14202/vetworld.2021.1622-1630
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hemato-Biochemical studies on Egyptian Buffaloes and Calves naturally infected with Foot and Mouth Disease Virus serotype SAT 22016 · 3 citations
  2. 2Novel pathologic findings and viral antigen distribution in cattle and buffalo calves naturally infected with Foot-and-Mouth disease virus2023 · 9 citations
  3. 3Some virological and pathological studies on Foot and Mouth disease in Egyptian buffalo2022
  4. 4A Newly Emerging Serotype A Strain in Foot-and-Mouth Disease Virus with Higher Severity and Mortality in Buffalo than in Cattle Calves in North Egypt2023 · 7 citations
  5. 5Pathological Studies on Foot and Mouth disease at Kaluobia Governorate2018