Key result
The combination of nifedipine and benazepril produced a significant fall in systolic and diastolic blood pressure for up to 9 to 12 hours in normotensive volunteers, unlike either drug alone.
Why the study?
Does the combination of nifedipine and benazepril reduce blood pressure compared to either drug alone in healthy normotensive volunteers?
Population
9 healthy male normotensive volunteers
Comparison
Single oral dose of nifedipine slow release 20… vs Single oral dose of nifedipine slow release 20…
Design
Other, open-label
Follow-up
24 hours post-dose
Authors
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Hypothesis-generating in normotensive volunteers; leaves open translation to hypertensive patients or practice change.
RCT (n=9)
Open-label
No
Does the combination of nifedipine and benazepril reduce blood pressure compared to either drug alone in healthy normotensive volunteers?
The renin-angiotensin system masks the hypotensive effect of dihydropyridines in normotensive individuals, which can be unmasked by the addition of an ACE inhibitor.
Jakobsen et al. (1992) conducted an RCT in Normotensive (n=9). Nifedipine and benazepril combination vs. Nifedipine alone and benazepril alone was evaluated on Blood pressure and heart rate over 24 h. The combination of nifedipine and benazepril produced a significant fall in systolic and diastolic blood pressure for up to 9 to 12 hours in normotensive volunteers, unlike either drug alone.
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