Key result
Auditory stimulation-induced increases in fetal heart rate decreased stroke volume from 3.7 to 3.0 ml (p<0.001) but left ventricular output remained unchanged at 0.48 liter/min.
Why the study?
Does increasing heart rate alter stroke volume and ventricular output in normal human fetuses?
Population
25 normal human fetuses, mean age 36 weeks
Comparison
Increasing heart rate by auditory stimulation… vs Prestimulation baseline state
Design
Cohort
Follow-up
Immediate (before and after stimulation)
Authors
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Indicates stable fetal left ventricular output despite heart rate rises; supports compensatory stroke volume mechanisms but remains hypothesis-generating.
Does increasing heart rate alter stroke volume and ventricular output in normal human fetuses?
Absolute Event Rate: 3% vs 3.7%
p-value: p=<0.001
In normal human fetuses, physiologic increases in heart rate decrease stroke volume but maintain constant ventricular output.
Kenny et al. (1987) studied Normal human fetus (n=25). Auditory stimulation vs. Prestimulation baseline was evaluated on Stroke volume (p=<0.001). Auditory stimulation-induced increases in fetal heart rate decreased stroke volume from 3.7 to 3.0 ml (p<0.001) but left ventricular output remained unchanged at 0.48 liter/min.
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