Key result
A single oral dose of diazepam significantly decreased delta P0.1/delta PETCO2 values compared to placebo (p<0.05), whereas zopiclone had no effect, with no significant difference between the two.
Why the study?
Does a single oral dose of diazepam or zopiclone alter respiratory center output in patients with moderate to severe chronic obstructive pulmonary disease?
Population
32 normocapnic and moderately hypoxemic patients between the ages of 21 and 69 with moderate to severe…
Comparison
One oral dose of diazepam or zopiclone vs Placebo
Design
RCT, 2 x 2 Latin-square design, double-blind
Authors
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Diazepam but not zopiclone blunts hypercapnic respiratory drive in COPD; warrants caution with benzodiazepines and extends RCT data on sedative selectivity.
RCT (n=32)
Double-blind
Latin-square design
Does a single oral dose of diazepam or zopiclone alter respiratory center output in patients with moderate to severe chronic obstructive pulmonary disease?
p-value: p=<0.05
A single oral dose of diazepam, but not zopiclone, significantly decreases respiratory center output in response to hypercapnia in patients with moderate to severe COPD.
Beaupré et al. (2009) conducted an RCT in Chronic obstructive pulmonary disease (n=32). Diazepam and Zopiclone vs. Placebo was evaluated on delta P0.1/delta PETCO2 values following CO2 rebreathing (p=<0.05). A single oral dose of diazepam significantly decreased delta P0.1/delta PETCO2 values compared to placebo (p<0.05), whereas zopiclone had no effect, with no significant difference between the two.
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