Key result
Nifedipine was more potent in inhibiting TEA-induced activation in canine and spontaneous rhythmic activity in human coronary arteries, whereas nitroglycerin and nitroprusside were more potent against NA-induced activation.
Population
Helical strips from canine coronary arteries and human coronary arteries excised postmortem
Comparison
Nifedipine, nitroglycerin, and nitroprusside… vs Comparison between the different vasodilators
Design
Preclinical
Authors
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May guide stimulus-specific vasodilator choice in coronary spasm; leaves open clinical translation from isolated arteries.
Nifedipine is more effective at inhibiting TEA-induced activation, while nitroglycerin and nitroprusside are more effective against noradrenaline-induced activation in coronary arteries.
Weinheimer et al. (1983) studied Canine and human coronary arteries. Nifedipine, Nitroglycerin, and Nitroprusside Sodium vs. Compared against each other was evaluated on Inhibitory effects on TEA-induced and NA-induced activation. Nifedipine was more potent in inhibiting TEA-induced activation in canine and spontaneous rhythmic activity in human coronary arteries, whereas nitroglycerin and nitroprusside were more potent against NA-induced activation.
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