Key result
Prophylactic intramuscular ephedrine 50 mg prior to caesarean section caused reactive hypertension in 90% of patients and significantly lowered umbilical venous pH (P=0.0001) compared to control.
Why the study?
Does prophylactic intramuscular ephedrine prior to caesarean section cause adverse maternal or neonatal effects in healthy parturients?
Population
30 healthy parturients undergoing caesarean section
Comparison
Intramuscular injection of ephedrine 25 mg or 50… vs Intramuscular injection of 0.9% sodium chloride
Design
RCT, randomly allocated, double-blind
Authors
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Avoid prophylactic IM ephedrine before caesarean; confirms maternal hypertension and neonatal acidosis risks in healthy parturients.
RCT (n=30)
Double-blind
randomly allocated
Does prophylactic intramuscular ephedrine prior to caesarean section cause adverse maternal or neonatal effects in healthy parturients?
Prophylactic intramuscular ephedrine prior to caesarean section is not recommended due to high rates of maternal hypertension and adverse neonatal acid-base changes.
Rout et al. (1992) conducted an RCT in Caesarean section (n=30). Ephedrine vs. 0.9% sodium chloride was evaluated on Reactive hypertension of 20% or greater from control. Prophylactic intramuscular ephedrine 50 mg prior to caesarean section caused reactive hypertension in 90% of patients and significantly lowered umbilical venous pH (P=0.0001) compared to control.
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