Key result
Prophylactic intravenous ephedrine did not decrease maternal hypotension (69% vs 70%) but increased the frequency of umbilical artery blood pH < 7.20 (10.6% vs 3.2%, P=0.024).
Why the study?
Does prophylactic ephedrine prevent maternal hypotension and improve neonatal outcomes in term healthy parturients undergoing regional anesthesia for cesarean section?
Population
Term healthy parturients (n = 122) scheduled for elective repeat cesarean section under regional anesthesia
Comparison
Prophylactic intravenous bolus of ephedrine 10… vs No prophylactic ephedrine (controls)
Design
Cohort
Authors
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Prophylactic ephedrine offers no maternal benefit and was associated with worse fetal acid-base status; leaves open optimal vasopressor strategies pending randomized trials.
Cohort (n=122)
Does prophylactic ephedrine prevent maternal hypotension and improve neonatal outcomes in term healthy parturients undergoing regional anesthesia for cesarean section?
Absolute Event Rate: 69% vs 70%
Prophylactic ephedrine does not prevent maternal hypotension during regional anesthesia for cesarean section and is associated with worse fetal acid-base status.
Shearer et al. (1996) conducted a cohort in Term healthy parturients scheduled for elective repeat cesarean section under regional anesthesia (n=122). Prophylactic intravenous ephedrine vs. No prophylactic ephedrine was evaluated on Incidence of maternal hypotension. Prophylactic intravenous ephedrine did not decrease maternal hypotension (69% vs 70%) but increased the frequency of umbilical artery blood pH < 7.20 (10.6% vs 3.2%, P=0.024).
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