Key result
Prophylactic ephedrine infusion resulted in lower systolic blood pressure and more rescue vasopressor doses compared to norepinephrine (P=0.04) during cesarean delivery under spinal anesthesia.
Why the study?
Ephedrine is typically the first-line treatment for maternal hypotension during cesarean section, but norepinephrine is gaining popularity in obstetric anesthesia.
Does prophylactic ephedrine versus norepinephrine infusion improve maternal hemodynamics and neonatal outcomes in patients undergoing cesarean delivery under spinal anesthesia?
Population
100 female patients aged over 21 prepared for elective cesarean section under spinal anesthesia
Comparison
Prophylactic ephedrine infusion vs norepinephrine infusion
Design
Prospective randomized double-blind trial
Authors
Loading...
Norepinephrine infusion provides superior hemodynamic stability versus ephedrine in spinal cesarean delivery; supports preferential use and further outcome trials.
RCT (n=100)
double-blind
randomized
Does prophylactic ephedrine versus norepinephrine infusion improve maternal hemodynamics and neonatal outcomes in patients undergoing cesarean delivery under spinal anesthesia?
p-value: p=<0.05
Prophylactic norepinephrine infusion provides superior maternal hemodynamic stability and reduces the need for rescue vasopressors compared to ephedrine during cesarean delivery under spinal anesthesia.
Fouda et al. (2026) conducted an RCT in elective cesarean section under spinal anesthesia (n=100). Ephedrine vs. Norepinephrine (4 mg/min) was evaluated on Maternal hemodynamics and neonatal outcome (p=<0.05). Prophylactic ephedrine infusion resulted in lower systolic blood pressure and more rescue vasopressor doses compared to norepinephrine (P=0.04) during cesarean delivery under spinal anesthesia.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: