Key result
Thermodilution cardiac output determination using 3 ml iced injectate did not cause serious haemodynamic alterations and accurately estimated right ventricular output (r > 0.9) under MI and PE.
Why the study?
Does thermodilution cardiac output measurement using iced injectate cause serious haemodynamic alterations in dogs with myocardial ischaemia or pulmonary oedema?
Population
Anaesthetized dogs with induced myocardial ischaemia (N=7) or pulmonary oedema (N=7)
Comparison
Thermodilution cardiac output measurement using… vs Dogs without myocardial ischaemia or pulmonary…
Design
Preclinical
Authors
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Supports feasibility of 3 ml iced thermodilution in canine MI/PE models; leaves open human validation before clinical use.
Does thermodilution cardiac output measurement using iced injectate cause serious haemodynamic alterations in dogs with myocardial ischaemia or pulmonary oedema?
Effect estimate: r > 0.9
Thermodilution cardiac output determination using iced injectate does not cause serious haemodynamic alterations and accurately estimates right ventricular output in canine models of myocardial ischaemia and pulmonary oedema.
Nishikawa et al. (1992) studied Myocardial ischaemia or pulmonary oedema (n=14). Thermodilution cardiac output determination vs. Dogs without myocardial ischaemia or pulmonary oedema was evaluated on Haemodynamic alterations and correlation with pulmonary blood flow (r > 0.9). Thermodilution cardiac output determination using 3 ml iced injectate did not cause serious haemodynamic alterations and accurately estimated right ventricular output (r > 0.9) under MI and PE.
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