Key result
Transcatheter paravalvular leakage closure via an open transapical approach had an 86% success rate, though moderate to severe residual leakage was associated with all-cause mortality (HR 3.9; P=0.03).
Why the study?
Does transcatheter PVL closure using an open transapical approach improve clinical outcomes in high-risk patients with severe symptomatic PVL?
Cohort (n=37)
No
Does transcatheter PVL closure using an open transapical approach improve clinical outcomes in high-risk patients with severe symptomatic PVL?
Hazard Ratio: 3.9 (95% CI 1.2–12.1)
p-value: p=0.03
Open transapical transcatheter PVL closure in high-risk patients is feasible with an 86% success rate and improves functional capacity, though residual PVL strongly predicts 1-year mortality.
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Residual leakage signals higher mortality after transapical PVL closure; leaves open randomized trials to confirm net benefit in high-risk patients.
Nijenhuis et al. (2014) conducted a cohort in Severe symptomatic paravalvular leakage (n=37). Transcatheter PVL closure using an open transapical approach was evaluated on All-cause mortality (associated with moderate to severe residual PVL) (HR 3.9, 95% CI 1.2-12.1, p=0.03). Transcatheter paravalvular leakage closure via an open transapical approach had an 86% success rate, though moderate to severe residual leakage was associated with all-cause mortality (HR 3.9; P=0.03).
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