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June 1, 1986The Journal of Pathology

Endothelial cell markers in vascular neoplasms: An immunohistochemical study comparing factor VIII‐related antigen, blood group specific antigens, 6‐keto‐PGF1 alpha, and Ulex europaeus 1 lectin

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Key result

Staining for Ulex europaeus 1 lectin appeared more sensitive than factor VIII-related antigen in identifying poorly differentiated vascular neoplasms and was the only marker for lymphangiomas.

Why the study?

Are Ulex europaeus 1 lectin and other markers more sensitive than factor VIII-related antigen in identifying endothelial cells in vascular neoplasms?

Population

Paraffin sections from formalin-fixed benign and malignant vascular neoplasms

Comparison

Immunohistochemical staining for Ulex europaeus… vs Immunohistochemical staining for factor…

Design

Other

Authors

DLDaniel LittleUniversity of Michigan–DearbornJSJonathan SaidUniversity of California, Los AngelesRSRobert J. SiegelGeneral Cardiology

Discussion

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Implication

May aid identification of poorly differentiated vascular neoplasms and lymphangiomas; leaves open validation against contemporary endothelial markers.

Study Design

Type

Observational

Structured PICO

Are Ulex europaeus 1 lectin and other markers more sensitive than factor VIII-related antigen in identifying endothelial cells in vascular neoplasms?

P
Population
Paraffin sections from formalin-fixed benign and malignant vascular neoplasms evaluated for endothelial cell markers.
E
Exposure
Immunohistochemical staining for Ulex europaeus 1 lectin, blood group A, B, and H, and the prostaglandin metabolite 6-keto-PGF1 alpha
C
Comparator
Immunohistochemical staining for factor VIII-related antigen
O
Outcome
Sensitivity in identifying endothelial cells in vascular neoplasmssurrogate

Ulex europaeus 1 lectin is a more sensitive immunohistochemical marker than factor VIII-related antigen for identifying endothelial cells in poorly differentiated vascular neoplasms and lymphangiomas.

Cite This Study

Little et al. (1986) conducted an observational in Benign and malignant vascular neoplasms. Ulex europaeus 1 lectin and other markers vs. Factor VIII-related antigen was evaluated on Sensitivity in identifying poorly differentiated neoplasms and lymphangiomas. Staining for Ulex europaeus 1 lectin appeared more sensitive than factor VIII-related antigen in identifying poorly differentiated vascular neoplasms and was the only marker for lymphangiomas.

synapsesocial.com/papers/6a930e1ac7154f4f5f4aa061https://doi.org/10.1002/path.1711490203
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ulex europaeus I Lectin as a Marker for Tumors Derived from Endothelial Cells1983 · 213 citations
  2. 2ABH Blood Group Isoantigen Expression in Breast Carcinomas—An Immunohistochemical Evaluation Using Monoclonal Antibodies1985 · 40 citations
  3. 3A, B, H antigens in transitional cell tumors of the urinary bladder.Correlation with the clinical course1979 · 138 citations
  4. 4Immunohistochemical Identification of Factor VIII-Related Antigen in Endothelial Cells of Cutaneous Lesions of Alleged Vascular Nature1981 · 240 citations