March 5, 2012Coronary Artery Disease
Brain natriuretic peptide in apical ballooning syndrome (Takotsubo/stress cardiomyopathy)
Key result
Apical ballooning syndrome was associated with a significantly higher BNP to peak troponin T ratio compared with STEMI controls (1089.4 vs 97.4, P=0.04).
Population
132 patients, including 57 prospectively diagnosed with apical ballooning syndrome and 75 matched controls.
Design
Case-control
Authors
Discussion
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Member takes
Implication
May aid differentiation of apical ballooning from STEMI; leaves open prospective validation of diagnostic utility.
Study Design
Type
Case-Control (n=132)
Structured PICO
P
Population
132 patients, including 57 with apical ballooning syndrome and 75 matched controls with STEMI or NSTEMI, evaluated for BNP and troponin T levels.
C
Comparator
Matched controls with ST-elevation myocardial infarction (STEMI) or non-ST-elevation myocardial infarction (NSTEMI)
O
Outcome
Brain natriuretic peptide (BNP) levels and BNP to peak troponin T ratiosurrogate
Main Result
Absolute Event Rate: 1089.4% vs 97.4%
p-value: p=0.04
BNP elevation is almost universal in apical ballooning syndrome, and the magnitude of elevation (especially the BNP to troponin T ratio) is significantly higher than in acute myocardial infarction.
Cite This Study
Ahmed et al. (2012) conducted a case-control in Apical ballooning syndrome (Takotsubo/stress cardiomyopathy) (n=132). Apical ballooning syndrome vs. STEMI and NSTEMI controls was evaluated on BNP to peak troponin T ratio (p=0.04). Apical ballooning syndrome was associated with a significantly higher BNP to peak troponin T ratio compared with STEMI controls (1089.4 vs 97.4, P=0.04).