Key result
Ro 40-5967 demonstrated a unique hemodynamic profile among calcium antagonists, characterized by very low negative inotropism and a lack of reflex tachycardia compared to verapamil, diltiazem, and amlodipine.
Why the study?
Does Ro 40-5967 have a different hemodynamic profile compared to verapamil, diltiazem, and amlodipine in conscious normotensive rats?
Population
Conscious normotensive rats
Comparison
Intravenous injection of Ro 40-5967 vs Intravenous injection of verapamil, diltiazem…
Design
Preclinical
Authors
Loading...
May inform calcium antagonist development; leaves open clinical translation in humans.
Does Ro 40-5967 have a different hemodynamic profile compared to verapamil, diltiazem, and amlodipine in conscious normotensive rats?
Ro 40-5967 demonstrates a unique hemodynamic profile among calcium antagonists with very low negative inotropism and lack of reflex tachycardia in a preclinical model.
Véniant et al. (1991) studied Conscious normotensive rats. Ro 40-5967 vs. Verapamil, diltiazem, and amlodipine was evaluated on Hemodynamic parameters (mean arterial pressure, left ventricular dP/dtmax, and heart rate). Ro 40-5967 demonstrated a unique hemodynamic profile among calcium antagonists, characterized by very low negative inotropism and a lack of reflex tachycardia compared to verapamil, diltiazem, and amlodipine.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: