Why the study?
Does Ro 40-5967 reduce left ventricular contractility less than diltiazem in normal rats and rats with chronic myocardial infarction?
Population
Normal rats and rats with chronic myocardial infarction induced by ligating the left coronary artery
Comparison
Ro 40-5967 (a new calcium antagonist) vs Diltiazem
Design
Preclinical
Authors
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May support safer calcium antagonists in LV dysfunction models; leaves open human translation.
Does Ro 40-5967 reduce left ventricular contractility less than diltiazem in normal rats and rats with chronic myocardial infarction?
Ro 40-5967 has a lesser negative inotropic effect than diltiazem in rats with chronic myocardial infarction, suggesting it may be a safer calcium antagonist for patients with left ventricular dysfunction.
Véniant et al. (1991) studied this question.
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