Why the study?
Does Ro 40-5967 improve myocardial function during ischemia in anesthetized dogs compared to verapamil?
Does Ro 40-5967 improve myocardial function during ischemia in anesthetized dogs compared to verapamil?
In a canine model of ischemia, the novel calcium antagonist Ro 40-5967 improved myocardial function and increased coronary flow without the negative inotropic effects seen with verapamil.
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May support further study of Ro 40-5967 in ischemic models; hypothesis-generating with no human applicability established.
Clozel et al. (1989) studied this question.
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