Key result
Intracerebroventricular injection of angiotensin II induced strong Fos-like immunoreactivity in specific brain regions that was abolished by an AT1 antagonist, differing from carbachol's effects.
Authors
Loading...
Hypothesis-generating for central AT1 signaling; leaves open translation to human cardiovascular control.
Rowland et al. (1994) studied this question. Intracerebroventricular injection of angiotensin II or carbachol vs. Angiotensin receptor antagonists (losartan, PD-123319, CGP-42112A) was evaluated on Fos-like immunoreactivity (FLI) in brain regions. Intracerebroventricular injection of angiotensin II induced strong Fos-like immunoreactivity in specific brain regions that was abolished by an AT1 antagonist, differing from carbachol's effects.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: