Key result
SH2B3 C784 T and MTHFR C677 T polymorphisms were associated with significantly higher SYNTAX scores compared to wild type (21.24 vs 15.29, p=0.00; and 20.34 vs 16.08, p=0.00, respectively).
Why the study?
Systemic inflammatory ratios are linked to myocardial infarction, but their association alongside coronary artery disease severity with SH2B3 C784 T and MTHFR C677 T polymorphisms in STEMI patients required investigation.
Are SH2B3 C784 T and MTHFR C677 T polymorphisms associated with increased systemic inflammatory markers and coronary artery disease severity in STEMI patients?
Observational (n=150)
Single-blind
Are SH2B3 C784 T and MTHFR C677 T polymorphisms associated with increased systemic inflammatory markers and coronary artery disease severity in STEMI patients?
SH2B3 C784 T and MTHFR C677 T polymorphisms are associated with elevated systemic inflammatory markers and higher SYNTAX scores in patients with STEMI.
Answers are grounded in this paper and cite their sources.
SH2B3/MTHFR SNPs may associate with inflammation and CAD severity in STEMI; hypothesis-generating, validation required before any clinical role.
Neutrophil-lymphocyte (NLR), platelet-lymphocyte (PLR), eosinophil-lymphocyte (ELR), and monocyte-lymphocyte (MLR) ratios are systemic inflammatory markers related to myocardial infarction. The aim of this study is to investigate the association of Src homology 2-B adapter protein 3 (SH2B3) C784 T and methylenetetrahydrofolate reductase (MTHFR) C677 T polymorphisms (SNP) with systemic inflammatory markers and the severity of coronary artery disease (CAD) in 150 ST-elevation myocardial infarction (STEMI) patients. Single nucleotide polymorphisms were genotyped using the tetra-primer amplification refractory mutation system-polymerase chain reaction (T-ARMS-PCR) method. The inflammatory markers were calculated. An interventional cardiologist blinded to other data assessed the SYNTAX (SX) Score. Eosinophil and platelet counts were significantly higher in SH2B3 variants than in the wild type. Additionally, SH2B3 variants had significantly higher ELR than the wild type (.12 ± .19 vs .25 ± .34, p = .018). NLR, PLR, ELR, and MLR were considerably higher in MTHFR variants than in the wild type ( p < .05). The SX score was significantly higher in both SH2B3 C784 T (21.24 ± 8.90 vs 15.29 ± 9.40, p = .00) and MTHFR C677 T (20.34 ± 10.21 vs 16.08 ± 8.39, p = .00) variants when compared with wild type. In conclusion, these polymorphisms are associated with several markers of systemic inflammation as well as the severity of CAD.
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Golestani et al. (2023) conducted an observational in ST-elevation myocardial infarction (STEMI) (n=150). SH2B3 C784 T and MTHFR C677 T polymorphisms vs. Wild type was evaluated on SYNTAX (SX) Score (p=.00). SH2B3 C784 T and MTHFR C677 T polymorphisms were associated with significantly higher SYNTAX scores compared to wild type (21.24 vs 15.29, p=0.00; and 20.34 vs 16.08, p=0.00, respectively).
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