Key result
Higher mean platelet volume (≥7.9 fl) was associated with an increased risk of ischemic stroke or CAD in patients with diabetes compared to lower MPV (HR 11.92; 95% CI 2.68-52.92; p=0.001).
Why the study?
Does higher mean platelet volume predict ischemic stroke or CAD events in patients with type 2 diabetes mellitus?
Population
200 Korean patients with type 2 diabetes mellitus
Comparison
Higher mean platelet volume (MPV) (≥7.9 fl) vs Lower mean platelet volume (MPV) (≤7.3 fl)
Design
Cohort
Follow-up
mean 28.4 months
Authors
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Does not warrant MPV-based risk stratification in T2DM; hypothesis-generating pending prospective validation.
Cohort (n=200)
Does higher mean platelet volume predict ischemic stroke or CAD events in patients with type 2 diabetes mellitus?
Hazard Ratio: 11.92 (95% CI 2.68–52.92)
Absolute Event Rate: 29.9% vs 2.8%
p-value: p=0.001
Higher mean platelet volume is a strong, independent predictor of ischemic stroke and coronary artery disease in Korean patients with type 2 diabetes.
Han et al. (2012) conducted a cohort in Type 2 diabetes mellitus (n=200). Higher mean platelet volume (≥7.9 fl) vs. Lower mean platelet volume (≤7.3 fl) was evaluated on composite of ischemic stroke/CAD events (HR 11.92, 95% CI 2.68-52.92, p=0.001). Higher mean platelet volume (≥7.9 fl) was associated with an increased risk of ischemic stroke or CAD in patients with diabetes compared to lower MPV (HR 11.92; 95% CI 2.68-52.92; p=0.001).
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