Key result
Applying sodium warfarin showed no positive influence on the inhibition of mineralization of polyurethane membranes in animals with a Total Artificial Heart.
Why the study?
Does sodium warfarin inhibit the mineralization of polyurethane membranes in animals with a Total Artificial Heart?
Observational
Does sodium warfarin inhibit the mineralization of polyurethane membranes in animals with a Total Artificial Heart?
Sodium warfarin does not appear to inhibit the mineralization of polyurethane membranes in animal models of Total Artificial Heart, a process directly related to survival time.
Warfarin does not inhibit polyurethane mineralization in animal TAH models; leaves open anticoagulation effects on device durability in humans.
The degree of mineralization of TAH membranes in animals is directly related to the survival time of animals with a TAH. Large differences in mineralization of the membranes among individual animals have been observed. These differences can be explained by the simultaneous presence of infection on biomaterials (polyurethane) as well as by different levels of natural inhibitors of mineralization. No positive influence of applying sodium warfarin for the inhibition of the mineralization was observed.
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Dostál et al. (1990) conducted an observational in Total Artificial Heart (TAH) implantation. Sodium warfarin was evaluated on Mineralization of TAH membranes. Applying sodium warfarin showed no positive influence on the inhibition of mineralization of polyurethane membranes in animals with a Total Artificial Heart.
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