The mammalian cdc2 protein kinase: mechanisms of regulation during the cell cycle

This is the authors' abstract. We don't add key points for this paper.

Recent experimental evidence has demonstrated the central role of the cdc2 protein kinase in the transition from G2 to M phase in eukaryotic cells. We shall review our knowledge of the mechanisms which coordinate activation of the kinase with cell cycle-specific events in mammalian cells.