Key result
The reovirus outer capsid protein σ3 is a zinc metalloprotein with distinct binding sites for zinc in its amino-terminal fragment and double-stranded RNA in its carboxy-terminal fragment.
Population
Mouse L cells infected with reovirus T3 Dearing, T1 Lang, and T2 Jones
Design
Preclinical
Authors
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Distinct σ3 domains may regulate viral transcription; leaves open functional roles and therapeutic targeting in reovirus infection.
The reovirus outer capsid protein sigma 3 contains distinct binding sites for zinc and dsRNA, which may be important for its regulatory effects on viral and host cell transcription and translation.
Schiff et al. (1988) studied Reovirus. Biochemical analysis of reovirus protein σ3 was evaluated. The reovirus outer capsid protein σ3 is a zinc metalloprotein with distinct binding sites for zinc in its amino-terminal fragment and double-stranded RNA in its carboxy-terminal fragment.
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