Key result
Patients with cardiac neurosis exhibited augmented cardiovascular and plasma catecholamine responses to dynamic exercise, with peak plasma epinephrine significantly higher than in patients with organic heart disease.
Why the study?
Does metoprolol improve exercise tolerance and reduce cardiovascular hyperactivity in patients with cardiac neurosis?
Population
77 subjects total: 34 patients with cardiac neurosis, 31 patients with organic heart disease, and 12 normal…
Comparison
Multistage treadmill exercise testing; a… vs Patients with organic heart disease and normal…
Design
Cross-sectional
Follow-up
2 weeks (for metoprolol subgroup)
Authors
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Augmented sympatho-adrenal responses in cardiac neurosis may inform beta-blocker hypotheses; leaves open any practice change pending prospective trials.
Cross-Sectional (n=77)
No
Does metoprolol improve exercise tolerance and reduce cardiovascular hyperactivity in patients with cardiac neurosis?
Absolute Event Rate: 108% vs 48%
p-value: p=<0.05
Patients with cardiac neurosis exhibit augmented sympatho-adrenal activity during exercise, and low-dose metoprolol effectively improves their exercise tolerance and reduces cardiovascular hyperactivity.
Miyakoda et al. (1990) conducted a cross-sectional in Cardiac neurosis (n=77). Cardiac neurosis vs. Organic heart disease and normal subjects was evaluated on Plasma epinephrine concentration at peak exercise in poor tolerance group (pg/ml) (p=<0.05). Patients with cardiac neurosis exhibited augmented cardiovascular and plasma catecholamine responses to dynamic exercise, with peak plasma epinephrine significantly higher than in patients with organic heart disease.
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