Key result
Droxicainide produced qualitatively and quantitatively similar electrophysiological and mechanical effects to lidocaine on isolated rat heart muscle, but was less potent.
Why the study?
Does droxicainide have similar electrophysiological and mechanical effects to lidocaine in isolated rat heart muscle?
Does droxicainide have similar electrophysiological and mechanical effects to lidocaine in isolated rat heart muscle?
Droxicainide exhibits class 1 anti-arrhythmic properties similar to lidocaine but with lower potency in isolated rat heart muscle.
Answers are grounded in this paper and cite their sources.
Droxicainide exhibits class I effects akin to lidocaine in rat myocardium; leaves open its development as a clinical antiarrhythmic.
A new antiarrhythmic drug, droxicainide, was compared with lidocaine in order to evaluate droxicainide's effect on heart muscle. Dose-response curves for electrophysiological and mechanical effects of the two drugs on spontaneously beating atria, electrically stimulated atria and papillary muscles isolated from rats were obtained. After increasing doses of both droxicainide and lidocaine sinus node automaticity decreased, atrial and ventricular excitability and contractile force decreased and refractoriness increased. The effects of the two drugs on atrial and ventricular muscle were qualitatively and quantitatively the same, but droxicainide was less potent. The results fit well with the concept that droxicainide is a class 1 anti-arrhythmic drug.
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Helgesen et al. (1984) studied this question. Droxicainide vs. Lidocaine was evaluated on Electrophysiological and mechanical effects (sinus node automaticity, excitability, contractile force, refractoriness). Droxicainide produced qualitatively and quantitatively similar electrophysiological and mechanical effects to lidocaine on isolated rat heart muscle, but was less potent.
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