Key result
Acute and chronic renal failure were associated with significantly reduced postheparin lipolytic activity at 10 minutes (7.82 and 8.44 vs 12.03 mumol FFA/mL/h, p < .01) compared to healthy controls.
Why the study?
Does acute and chronic renal failure alter lipid profiles and postheparin lipolytic activity compared to healthy controls?
Population
21 patients with acute renal failure, 24 with chronic renal failure, and 23 healthy volunteers
Comparison
Intravenous heparin to measure postheparin… vs Healthy volunteers
Design
Case-control
Authors
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May underlie hypertriglyceridemia in renal failure; hypothesis-generating and should not yet change practice.
Observational (n=68)
Does acute and chronic renal failure alter lipid profiles and postheparin lipolytic activity compared to healthy controls?
Absolute Event Rate: 7.82% vs 12.03%
p-value: p=< .01
Both acute and chronic renal failure are associated with hypertriglyceridemia and reduced postheparin lipolytic activity compared to healthy controls.
Gupta et al. (1994) conducted an observational in Acute and Chronic Renal Failure (n=68). Renal failure (acute and chronic) vs. Healthy volunteers was evaluated on Postheparin lipolytic activity (PHLA) at 10 min (p=< .01). Acute and chronic renal failure were associated with significantly reduced postheparin lipolytic activity at 10 minutes (7.82 and 8.44 vs 12.03 mumol FFA/mL/h, p < .01) compared to healthy controls.
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