Key result
Uremia was associated with reduced postheparin lipolytic activity in all 10 patients, but serum triglycerides were elevated (>190 mg/100 ml) in only six, suggesting other factors drive hyperlipemia.
Population
10 non-nephrotic uremic patients undergoing twice-weekly hemodialysis
Design
Cross-sectional
Authors
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Reduced postheparin lipolytic activity in uremia does not invariably raise triglycerides; leaves open other drivers and requires prospective confirmation.
Observational (n=10)
Reduced postheparin lipolytic activity in uremia may be partly due to a circulating inhibitor, but other factors are likely more important for developing hypertriglyceridemia.
Boyer et al. (1970) conducted an observational in Uremia with hypertriglyceridemia (n=10). Uremia vs. Normal subjects was evaluated on Fasting plasma triglyceride levels and postheparin lipolytic activity (PHLA). Uremia was associated with reduced postheparin lipolytic activity in all 10 patients, but serum triglycerides were elevated (>190 mg/100 ml) in only six, suggesting other factors drive hyperlipemia.
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