Key result
Tachycardia gradually increased plasma iANP in anesthetized rabbits, reaching almost 200 pg/ml after 20 minutes, suggesting release may not simply be a consequence of increased atrial pressure.
Why the study?
Does tachycardia increase plasma immunoreactive atrial natriuretic peptide (iANP) levels in anesthetized rabbits?
Population
Anesthetized rabbits
Comparison
Tachycardia (stimulation) vs Baseline (prior to tachycardia)
Design
Preclinical
Follow-up
20 minutes
Authors
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Should not alter clinical management; leaves open non-pressure mechanisms of ANP release in humans.
Does tachycardia increase plasma immunoreactive atrial natriuretic peptide (iANP) levels in anesthetized rabbits?
The gradual increase in iANP during tachycardia suggests its release may not simply be a consequence of increased atrial pressure.
Rankin et al. (1987) studied Tachycardia. Tachycardia vs. Baseline was evaluated on Plasma concentration of immunoreactive atrial natriuretic peptide (iANP). Tachycardia gradually increased plasma iANP in anesthetized rabbits, reaching almost 200 pg/ml after 20 minutes, suggesting release may not simply be a consequence of increased atrial pressure.
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