Key result
A combination of NMR techniques completed a molecular walk along the covalent framework of amiodarone and its metabolites, removing ambiguities in their 1H and 13C NMR assignments.
This study provides definitive 1H and 13C NMR spectral assignments for the antiarrhythmic drug amiodarone and its metabolites.
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May support metabolite analysis in amiodarone research; leaves open clinical translation pending human data.
The 1H and 13C NMR spectra of amiodarone, a potent cardiac antiarrhythmic agent, desethylamiodarone, the main metabolite of amiodarone and desoxoamiodarone, a less toxic form of amiodarone, were assigned using a combination of NMR techniques. Methods applied include 1H‐1H COSY, homonuclear Hartmann–Hahn relayed spectroscopy (HOHAHA), broadband decoupled 1H–13C chemical shift correlation, long‐range 1H–13C chemical shift correlation and selective INEPT. This combination of NMR experiments has completed a molecular walk along the covalent framework of the cardiac drug molecules, and removed ambiguities in their 1H and 13C NMR assignments.
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Ribeiro et al. (1991) studied this question. 1H and 13C NMR analyses was evaluated on 1H and 13C NMR assignments. A combination of NMR techniques completed a molecular walk along the covalent framework of amiodarone and its metabolites, removing ambiguities in their 1H and 13C NMR assignments.
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