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September 1, 1984Journal of Mass Spectrometry

High-performance liquid chromatographic isolation and fast atom bombardment mass spectrometric identification of di-N-desethylamiodarone, a new metabolite of amiodarone in the dog

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Population

Dogs treated with amiodarone

Design

Preclinical

Authors

RLRoberto LatiniHeart Failure & TransplantRRR. ReginatoABAlma L. BurlingameQB3

Discussion

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Implication

May contribute to amiodarone effects in dogs; hypothesis-generating and leaves open human relevance or practice change.

Structured PICO

P
Population
Dogs treated with amiodarone
I
Intervention
Amiodarone
O
Outcome
Identification of amiodarone metabolites in blood and myocardiumsurrogate

Identification of a new amiodarone metabolite (DDEA) with high myocardial affinity in dogs suggests it may play a role in the drug's pharmacodynamics or side effects.

Cite This Study

Latini et al. (1984) studied this question.

synapsesocial.com/papers/6a7a0fb24353fbf06002134bhttps://doi.org/10.1002/bms.1200110906
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Identification and measurement of desethylamiodarone in blood plasma specimens from amiodarone-treated patients1982 · 60 citations
  2. 2Secondary ion mass spectrometry with cesium ion primary beam and liquid target matrix for analysis of bioorganic compounds1982 · 285 citations