Key result
The Sm-D protein was resolved into three distinct proteins (D1, D2, and D3) that react differentially with anti-Sm autoantibodies from patients with systemic lupus erythematosus.
Population
Purified snRNPs U1, U2, U4/U6 and U5 isolated from HeLa cells and mouse cells, and anti-Sm autoantibodies…
Design
Preclinical
Authors
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Isoform distinction of Sm-D may sharpen SLE autoantibody interpretation; leaves open isoform-specific roles in disease.
High-TEMED gel electrophoresis reveals that the common snRNP protein D consists of three distinct proteins (D1, D2, D3) that are differentially recognized by autoantibodies in systemic lupus erythematosus.
Lehmeier et al. (1990) studied Systemic lupus erythematosus (n=38). Anti-Sm autoantibodies was evaluated on Differential reactivity of anti-Sm autoantibodies with D1, D2, and D3 proteins. The Sm-D protein was resolved into three distinct proteins (D1, D2, and D3) that react differentially with anti-Sm autoantibodies from patients with systemic lupus erythematosus.
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