Key result
The weighted prevalence of valvular heart disease in the general Chinese population aged 35 years or older was 3.8%, with rheumatic heart disease remaining the leading etiology (55.1%).
Why the study?
The epidemiology of valvular heart disease has changed markedly over the last 50 years worldwide, but the prevalence and features of VHD in China were unknown.
Cross-Sectional (n=31,499)
Yes
In China, the estimated prevalence of valvular heart disease in adults aged ≥35 years is 3.8%, with rheumatic heart disease remaining the predominant etiology despite a significant increase in degenerative cases.
May inform valvular disease resource planning in China; leaves open whether etiology is shifting with development.
BACKGROUND: The epidemiology of valvular heart disease (VHD) has changed markedly over the last 50 years worldwide, and the prevalence and features of VHD in China are unknown. The objective of this study was to investigate the current status and etiology of VHD in China. METHODS: We used a cross-sectional national survey with stratified multistage random sampling from the general Chinese population to estimate the VHD burden. Data on demographic characteristics, medical history, physical examination, blood tests, and potential etiology were collected. Echocardiography was used to detect VHD. RESULTS: The national survey enrolled 34,994 people aged 35 years or older across China. Overall, 31,499 people were included in the final analysis, and 1309 participants were diagnosed with VHD. The weighted prevalence was 3.8%, with an estimated 25 million patients in China. The prevalence of VHD increased with age and was higher in participants with hypertension or chronic kidney disease than in their counterparts. Among participants with VHD, 55.1% were rheumatic and 21.3% were degenerative. The proportion of rheumatic decreased with age, and the proportion of degenerative rose with age. However, the prevalence of rheumatic disease was still higher in the elderly population than in the younger population. Logistic regression revealed that age and hypertension were correlated with VHD. CONCLUSIONS: In China, rheumatic heart disease was still the major cause of the VHD, with a significant increase in degenerative heart disease. Age and hypertension are important and easily identifiable markers of VHD.
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Yang et al. (2021) conducted a cross-sectional in Valvular heart disease (n=31,499). General population was evaluated on Weighted prevalence of valvular heart disease (95% CI 2.6-5.6). The weighted prevalence of valvular heart disease in the general Chinese population aged 35 years or older was 3.8%, with rheumatic heart disease remaining the leading etiology (55.1%).
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