Key result
Preclinical testing of the Heartmate III left ventricular assist system in calves demonstrated good in vivo performance at an average flow rate of 6 L/min, alongside 16-40 months of in vitro reliability.
Population
Preclinical model (calves) and in vitro testing (13 LVADs)
Design
Preclinical
Follow-up
16 to 40 months (in vitro testing)
Authors
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Supports progression to human trials of HeartMate III; leaves open clinical safety and efficacy.
The HeartMate III LVAD with a magnetically levitated rotor demonstrates promising preclinical in vivo performance and long-term in vitro reliability.
Farrar et al. (2007) studied Advanced heart failure. Heartmate III Centrifugal Left Ventricular Assist System was evaluated. Preclinical testing of the Heartmate III left ventricular assist system in calves demonstrated good in vivo performance at an average flow rate of 6 L/min, alongside 16-40 months of in vitro reliability.
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