What question did this study set out to answer?

To compare the effects of three centrifugal blood pumps and a conventional roller pump on hemolysis, platelet function, and plasmatic coagulation in vitro.

August 1, 1999The International Journal of Artificial Organs

Platelet Function and Hemolysis in Centrifugal Pumps: In Vitro Investigations

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Authors

DSD. Steines DWD. Westphal CGChristof A. GöbelUniversidad Autónoma Metropolitana

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Implication

In vitro comparative study demonstrates divergent platelet inhibition and hemolysis in circulating blood, suggesting pump surface area drives severe coagulation dysfunction.

Key Points

To compare the effects of three centrifugal blood pumps and a conventional roller pump on hemolysis, platelet function, and plasmatic coagulation in vitro.
Tested three centrifugal pumps (BioMedicus BP-80, St. Jude Isoflow, Sarns Delphin) alongside a Stockert roller pump in an in vitro circulation model for 360 minutes using ACD anticoagulation.
Measured normalized index of hemolysis (NIH), platelet counts, thromboplastin and partial thromboplastin times, and resonance thrombography (RTG) parameters.
Normalized index of hemolysis after 360 minutes was lowest in the Isoflow (0.008±0.004 g/100 l) and BP-80 (0.018±0.017 g/100 l), compared to the roller pump (0.049±0.010 g/100 l) and Delphin (0.085±0.051 g/100 l).
Platelet function was severely inhibited by the BP-80 pump, with RTG platelet time surging to 358%±150% of baseline, compared to 42%±29% for Isoflow, 40%±20% for Delphin, and 12%±10% for the roller pump.
Plasmatic coagulation was activated across all circuits, while the large surface area of the BP-80 led to extensive platelet activation, impaired fibrin polymerization, and plasminogen activation.

Cite This Study

Steines et al. (1999) studied this question.

synapsesocial.com/papers/6a93bd59ec4af56311ebc403 https://doi.org/10.1177/039139889902200806

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Implication

In vitro comparative study demonstrates divergent platelet inhibition and hemolysis in circulating blood, suggesting pump surface area drives severe coagulation dysfunction.

Platelet Function and Hemolysis in Centrifugal Pumps: In Vitro Investigations

Discussion

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Implication

Key Points

Cite This Study

Platelet Function and Hemolysis in Centrifugal Pumps: In Vitro Investigations

Discussion

Member takes

Implication

Key Points

Cite This Study

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