Key result
Dilated aortic models with bicuspid aortic valves exhibited abnormal hemodynamics with elevated flow skewness, eccentricity, and wall shear stress compared to non-dilated aortas.
Why the study?
Bicuspid aortic valve aortopathy remains difficult to manage clinically due to its heterogeneity, necessitating further assessment of related aortic hemodynamics.
Observational
Patient-specific computational modeling demonstrates that abnormal hemodynamics, including elevated flow skewness and wall shear stress, may contribute to progressive aortic enlargement in patients with bicuspid aortic valves and dilated aortas.
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Abnormal flow patterns may contribute to aortic dilation in bicuspid valves; hypothesis-generating and requires prospective validation before clinical consideration.
Oliveira et al. (2019) conducted an observational in Bicuspid aortic valve aortopathy. Bicuspid aortic valve with dilated ascending aorta vs. Non-dilated aortas was evaluated on Systolic hemodynamic indexes and wall stresses. Dilated aortic models with bicuspid aortic valves exhibited abnormal hemodynamics with elevated flow skewness, eccentricity, and wall shear stress compared to non-dilated aortas.
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