Key result
Laboratory APTT had the highest diagnostic accuracy for monitoring heparin status (AUC 0.978), but CoaguChek Plus APTT (AUC 0.872) was adopted for point-of-care due to faster turnaround times.
Why the study?
What is the diagnostic accuracy of bedside coagulation procedures compared to laboratory APTT for monitoring anticoagulation status in patients receiving heparin during percutaneous coronary angioplasty?
Population
Patients who received heparin therapy during percutaneous coronary angioplasty.
Comparison
Bedside coagulation procedures vs Laboratory APTT and automated chromogenic…
Design
Cross-sectional
Authors
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Supports POC APTT adoption for faster heparin monitoring in PCI; leaves open prospective outcome validation before practice change.
Observational
What is the diagnostic accuracy of bedside coagulation procedures compared to laboratory APTT for monitoring anticoagulation status in patients receiving heparin during percutaneous coronary angioplasty?
While laboratory APTT has the highest diagnostic accuracy for monitoring heparin during PCI, point-of-care whole blood APTT offers a practical alternative due to inadequate laboratory turnaround times.
Solomon et al. (1998) conducted an observational in Heparin therapy during percutaneous coronary angioplasty. Bedside coagulation procedures (CoaguChek Plus APTT, Hemochron ACT, TAS APTT) vs. Laboratory APTT was evaluated on Diagnostic accuracy (Area under the ROC curve) for detecting heparin concentrations ≥ 0.3 U/mL. Laboratory APTT had the highest diagnostic accuracy for monitoring heparin status (AUC 0.978), but CoaguChek Plus APTT (AUC 0.872) was adopted for point-of-care due to faster turnaround times.
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