What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Borderline hypertension (n=40). Intervention: Borderline hypertension vs. Normotension. Primary outcome: Intima-media thickness of the common carotid artery (CCA) (p=<0.01).

What question did this study set out to answer?

To evaluate structural alterations in the carotid arteries and left ventricle in young adults with borderline hypertension compared to normotensive controls using ultrasound.

November 18, 2008Cardiology

Ultrasonographic Evaluation of Cardiac and Vascular Changes in Young Borderline Hypertensives

Q: What are the key findings of this study?

Young borderline hypertensives had significantly higher common carotid artery intima-media thickness compared to normotensives (0.6 vs. 0.4 mm, p<0.01).

Q: What question did this study set out to answer?

To evaluate structural alterations in the carotid arteries and left ventricle in young adults with borderline hypertension compared to normotensive controls using ultrasound.

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Key result

Young borderline hypertensives had significantly higher common carotid artery intima-media thickness compared to normotensives (0.6 vs. 0.4 mm, p<0.01).

Why the study?

Are there ultrasonographic cardiac and vascular changes in young borderline hypertensives compared to normotensive subjects?

Population

40 young subjects, comprising 20 borderline hypertensives and 20 normotensive controls.

Design

Case-control

Authors

LLLaura LonatiJagiellonian University CCCesare CuspidiPreventive Cardiology LSLorena SampieriUniversity of Milan

Discussion

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Implication

Young borderline hypertensive patients already exhibit significant increases in carotid intima-media thickness and left ventricular mass compared to normotensive controls.

Key Points

To evaluate structural alterations in the carotid arteries and left ventricle in young adults with borderline hypertension compared to normotensive controls using ultrasound.
Enrolled 20 young borderline hypertensive patients (mean age 24 ± 4 years) and 20 normotensive controls (mean age 23 ± 6 years).
Measured blood pressure and calculated left ventricular mass index via echocardiography.
Scanned both carotid axes in transverse and longitudinal views to determine common carotid artery and bifurcation intima-media thickness 20 mm caudally to the flow divider.
Borderline hypertensives demonstrated significantly higher blood pressure (147.8 ± 10.5/90.7 ± 6.6 vs. 120.5 ± 11.5/78.0 ± 5.4 mm Hg, p < 0.01) and left ventricular mass index (102.5 ± 15.3 vs. 90.5 ± 14.3 g/m², p < 0.05) than controls.
Intima-media thickness was significantly increased in borderline hypertensives at both the common carotid artery (0.6 ± 0.08 vs. 0.4 ± 0.05 mm, p < 0.01) and the bifurcation (0.7 ± 0.08 vs. 0.5 ± 0.08 mm, p < 0.01).
Carotid wall thickness correlated significantly with left ventricular mass index across the total study population.

Study Design

Type

Cross-Sectional (n=40)

Structured PICO

Are there ultrasonographic cardiac and vascular changes in young borderline hypertensives compared to normotensive subjects?

Population

40 young adults (20 borderline hypertensives and 20 normotensives) evaluated for ultrasonographic cardiac and vascular changes.

Comparator

Normotensive control subjects

Outcome

Intima-media thickness of the common carotid artery (CCA) and its bifurcation (BIF)surrogate

Main Result

Absolute Event Rate: 0.6% vs 0.4%

p-value: p=<0.01

Young borderline hypertensive patients already exhibit significant increases in carotid intima-media thickness and left ventricular mass compared to normotensive controls.

Cite This Study

Lonati et al. (2008) conducted a cross-sectional in Borderline hypertension (n=40). Borderline hypertension vs. Normotension was evaluated on Intima-media thickness of the common carotid artery (CCA) (p=<0.01). Young borderline hypertensives had significantly higher common carotid artery intima-media thickness compared to normotensives (0.6 vs. 0.4 mm, p<0.01).

synapsesocial.com/papers/6a93cb14277b71ec04c09801 https://doi.org/10.1159/000175985

Topics

Hypertension management Echocardiography

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Implication

Young borderline hypertensive patients already exhibit significant increases in carotid intima-media thickness and left ventricular mass compared to normotensive controls.

Ultrasonographic Evaluation of Cardiac and Vascular Changes in Young Borderline Hypertensives

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Topics

Ultrasonographic Evaluation of Cardiac and Vascular Changes in Young Borderline Hypertensives

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Also Consider

Topics

Also Consider