Key result
In patients with essential hypertension, left ventricular hypertrophy was associated with significantly higher intima-media thickness of the common carotid artery (0.85 vs 0.65 mm; P<0.01).
Observational (n=40)
Absolute Event Rate: 0.85% vs 0.65%
p-value: p=< 0.01
In patients with essential hypertension, the presence of left ventricular hypertrophy is significantly associated with increased carotid intima-media thickness, suggesting parallel cardiac and vascular structural changes.
Supports parallel cardiac-vascular remodeling in hypertension; hypothesis-generating and should not change practice without prospective data.
High-resolution ultrasonography is a noninvasive technique that allows to investigate the cardiovascular system, in particular the wall thickness and the lumen diameter of the arteries with accuracy and reproducibility. We measured the intima-media thickness of the common carotid artery (CCA) and of its bifurcation (BIF) in 40 patients with essential hypertension, 20 of them with left ventricular hypertrophy (LVH; age 42 +/- 10 years) and 20 without LVH (age 44 +/- 12 years); no other major cardiovascular risk factor was present in all the patients. Both carotid axes have been scanned from different views (anterior, lateral, posterior) on a transversal and longitudinal section using a high-resolution steerable linear array of 5.0 MHz. Carotid diameter and thickness were measured in the longitudinal section. CCA parameters were assessed 20 mm caudally to the flow divider. In patients with LVH, blood pressure (172 +/- 21/108 +/- 9 mm Hg) and left ventricular mass index (156 +/- 38 g/m2) were significantly (p < 0.01) higher than in patients without LVH (blood pressure: 158 +/- 11/99 +/- 12 mm Hg; left ventricular mass index: 98 +/- 10 g/m2), while there was no difference in serum glycemia, triglycerides, total and fractioned cholesterol levels. The intima-media thickness of both the CCA and BIF was significantly higher in the hypertensives with LVH (CCA: 0.85 +/- 0.02 vs. 0.65 +/- 0.02 mm; BIF: 0.93 +/- 0.04 vs. 0.70 +/- 0.03 mm, p < 0.01). There was a statistically significant correlation between the carotid wall thickness and the left ventricular mass index.(ABSTRACT TRUNCATED AT 250 WORDS)
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Cuspidi et al. (2008) conducted an observational in Essential hypertension (n=40). Left ventricular hypertrophy vs. No left ventricular hypertrophy was evaluated on Intima-media thickness of the common carotid artery (CCA) (p=< 0.01). In patients with essential hypertension, left ventricular hypertrophy was associated with significantly higher intima-media thickness of the common carotid artery (0.85 vs 0.65 mm; P<0.01).
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