Arterial wall thickening at different sites and its association with left ventricular hypertrophy in newly diagnosed essential hypertension
Key result
Left ventricular hypertrophy in newly diagnosed hypertension was associated with greater carotid (0.84 vs 0.71 mm, P<0.0001) and femoral (0.77 vs 0.64 mm, P<0.0001) intima-media thickness.
Population
96 newly diagnosed, never-treated, uncomplicated hypertensive subjects aged < 55 years
Design
Cross-sectional
Authors
Discussion
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Implication
Association suggests parallel cardiac-vascular remodeling in early hypertension; hypothesis-generating, needs longitudinal confirmation before practice change.
Study Design
Type
Cross-Sectional (n=96)
Structured PICO
P
Population
96 newly diagnosed, never-treated, uncomplicated hypertensive adults aged < 55 years.
O
Outcome
Association between carotid and femoral intima-media thickness (IMT) and left ventricular (LV) mass/hypertrophysurrogate
Main Result
Absolute Event Rate: 0.84% vs 0.71%
p-value: p=< .0001
In early-stage essential hypertension, arterial wall thickening is a diffuse process occurring in parallel at the carotid and femoral levels and is positively associated with left ventricular hypertrophy.
Cite This Study
Vaudo et al. (2000) conducted a cross-sectional in Essential hypertension (n=96). Left ventricular hypertrophy vs. No left ventricular hypertrophy was evaluated on Carotid intima-media thickness (mm) (p=< .0001). Left ventricular hypertrophy in newly diagnosed hypertension was associated with greater carotid (0.84 vs 0.71 mm, P<0.0001) and femoral (0.77 vs 0.64 mm, P<0.0001) intima-media thickness.