What question did this study set out to answer?

December 1, 2009Angiology

Carotid Intima-Media Thickness in Asymptomatic Patients With Arterial Hypertension Without Clinical Cardiovascular Disease: Relation With Left Ventricular Geometry and Mass and Coexisting Risk Factors

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Why the study?

Does carotid intima-media thickness correlate with left ventricular geometric remodeling and cardiovascular risk factors in asymptomatic essential hypertensives?

Population

265 subjects, comprising 198 asymptomatic, never treated, essential hypertensives without clinical…

Design

Cross-sectional

Authors

VBVitantonio Di BelloUniversity of Pisa SCScipione CarerjCardiac Imaging FPFrancesco PerticoneGeneral Cardiology

Discussion

Member takes

Implication

Supports concurrent vascular and myocardial remodeling in hypertension; leaves open causal and prognostic implications.

Key Points

To assess the relationship between carotid intima-media thickness, cardiovascular risk factors, and left ventricular geometry and mass in asymptomatic, untreated essential hypertension.
Evaluated 198 asymptomatic, never-treated patients with essential hypertension (mean age 58.2 ± 13 years) and 67 age- and gender-matched healthy controls.
Conducted complete clinical examinations, 2D Doppler echocardiography, and vascular echography to quantify carotid intima-media thickness and left ventricular geometric patterns.
Carotid intima-media thickness was highest in patients with concentric left ventricular hypertrophy and progressively increased alongside the number of coexisting cardiovascular risk factors (P < 0.001).
Carotid intima-media thickness correlated significantly with left ventricular mass (r = 0.35, P < 0.0001) and pulse pressure (r = 0.19, P < 0.006).
Carotid remodeling and left ventricular hypertrophy were more pronounced in older individuals, patients with higher systolic blood pressure, and those with multiple cardiovascular risk factors.

Structured PICO

Does carotid intima-media thickness correlate with left ventricular geometric remodeling and cardiovascular risk factors in asymptomatic essential hypertensives?

Population

265 subjects, comprising 198 asymptomatic, never treated, essential hypertensives (NYHA I, mean age 58.2 +/- 13) without clinical cardiovascular disease, and 67 age-gender matched healthy subjects.

Comparator

67 age-gender matched healthy subjects

Outcome

Interactions between Carotid Intima-Media Thickness (IMT), hypertension, cardiovascular risk factors, and left ventricular geometric remodelingsurrogate

In asymptomatic essential hypertensives, carotid intima-media thickness correlates significantly with left ventricular mass and the number of cardiovascular risk factors, indicating parallel vascular and cardiac remodeling.

Cite This Study

Bello et al. (2009) studied this question.

synapsesocial.com/papers/6a858e56f047f857d83db1cb https://doi.org/10.1177/0003319708329337

Topics

Hypertension management

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Carotid Intima-Media Thickness in Asymptomatic Patients With Arterial Hypertension Without Clinical Cardiovascular Disease: Relation With Left Ventricular Geometry and Mass and Coexisting Risk Factors

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Carotid Intima-Media Thickness in Asymptomatic Patients With Arterial Hypertension Without Clinical Cardiovascular Disease: Relation With Left Ventricular Geometry and Mass and Coexisting Risk Factors

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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