Key result
In patients with type 2 diabetes and diabetic neuropathy, the CVR-R difference (CVR-Rdif) was significantly and inversely correlated with maximum carotid intima-media thickness (β = -0.34, p=0.042).
Cross-Sectional (n=47)
No
Effect estimate: β = -0.34
p-value: p=0.042
The difference in the coefficient of variation in R-R intervals between deep breathing and rest (CVR-Rdif) correlates with carotid intima-media thickness, suggesting its utility as a noninvasive clinical index for atherosclerosis in patients with diabetic neuropathy.
CVR-Rdif was associated with carotid IMT in diabetic neuropathy; hypothesis-generating for noninvasive atherosclerosis assessment, requires validation.
We examined the relationship between the coefficient of variation in the R-R intervals (CVR-R) using electrocardiograms and the ultrasonic intima-media thickness (IMT) of the carotid artery, an atherosclerotic parameter, in type 2 diabetes mellitus (DM) patients with diabetic neuropathy (n=47, males/females: 29/18; mean age: 62 years). In this study, the CVR-R-related indexes, including CVR-R at rest (CVR-R(rest)), CVR-R with deep breaths (CVR-R(breath)) and their difference (CVR-R(breath) minus CVR-R(rest): CVR-R(dif)), were defined. Data such as body mass index, smoking habits, hemoglobin A1c, blood pressure, and serum low-density lipoprotein were collected. A significant inverse correlation was observed between max-IMT and CVR-R(dif) (beta=-0.34, p=0.042), but not CVR-R(rest) or CVR-R(breath), in multivariate analyses adjusted for all the data. Therefore, the CVR-R(dif) may serve as a clinical index for the diabetic autonomic neuropathy-atherosclerosis relation in type 2 DM patients.
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Miyamoto et al. (2010) conducted a cross-sectional in Type 2 diabetes mellitus with diabetic neuropathy (n=47). CVR-R difference (CVR-Rdif) was evaluated on Correlation between CVR-Rdif and maximum carotid intima-media thickness (max-IMT) (β = -0.34, p=0.042). In patients with type 2 diabetes and diabetic neuropathy, the CVR-R difference (CVR-Rdif) was significantly and inversely correlated with maximum carotid intima-media thickness (β = -0.34, p=0.042).
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