Key result
A microneutralization test using human diploid cells (WI-38) showed good correlation with other cells for determining rhinovirus and coxsackievirus A antibody titers.
Population
Human diploid cells (WI-38)
Comparison
Microneutralization test in Microtiter plates vs Neutralization tests in other cells
Design
Other
Authors
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May simplify large-scale serological research; leaves open clinical validation before routine diagnostic use.
The WI-38 Microtiter method provides a simple and economical approach for large-scale serological evaluation of viral antibodies.
Kriel et al. (1969) studied Rhinovirus and coxsackievirus A antibody determination. Microneutralization test in human diploid cells (WI-38) vs. Neutralization tests in other cells was evaluated on Correlation between neutralization tests in WI-38 and other cells. A microneutralization test using human diploid cells (WI-38) showed good correlation with other cells for determining rhinovirus and coxsackievirus A antibody titers.
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