Key result
WI-38 microneutralization testing correlates well with other cells for determining rhinovirus and coxsackievirus A titers.
Why the study?
A simple and economical method for large-scale serological evaluation of antibodies to rhinovirus and coxsackievirus in human diploid cells was needed.
Population
Human diploid cells (WI-38) and other cells
Comparison
WI-38 Microtiter method vs neutralization tests in other cells
Design
Method description and correlation comparison
Authors
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May support economical research serosurveys for rhinoviruses; animal data leaves open clinical adoption.
The WI-38 Microtiter method provides a simple and economical system for large-scale serological evaluation of antibodies for rhinoviruses and coxsackie A viruses.
Kriel et al. (1969) studied Rhinovirus and Coxsackievirus A antibody determination. Microneutralization test in human diploid cells (WI-38) vs. Neutralization tests in other cells was evaluated on Correlation between neutralization tests in WI-38 and other cells. A microneutralization test using human diploid cells (WI-38) showed good correlation with other cells for determining rhinovirus and coxsackievirus A antibody titers.
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