Key result
An abnormal biphasic waveform on APTT analysis was shown to be useful in predicting a poor prognosis, often pre-empting infection, DIC, and death.
Why the study?
Does an abnormal biphasic waveform on APTT analysis predict infection, DIC, and death in patients in a district general hospital?
Observational
No
Does an abnormal biphasic waveform on APTT analysis predict infection, DIC, and death in patients in a district general hospital?
An abnormal biphasic waveform on APTT analysis serves as a useful prognostic marker for predicting severe outcomes like infection, DIC, and death.
May identify high-risk patients early in district hospitals; hypothesis-generating and requires prospective validation before practice change.
Activated partial thromboplastin time analysis creates waveforms of light transmittance against time. An abnormal biphasic waveform has been linked to morbidity and mortality. This study aims to quantify this link for patients in a district general hospital and determine the prognostic implications of the biphasic waveform. Data were collected over a 5-month period and analysed retrospectively to ascertain rates of infection, disseminated intravascular coagulation (DIC) and death. This was followed by a one month prospective study to assess prognostic implications. Rates of infection, DIC and death were high in this study population. The biphasic waveform often pre-empts these outcomes and is shown to be useful in predicting a poor prognosis.
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Mair et al. (2007) conducted an observational in Patients in a district general hospital. Abnormal biphasic waveform on APTT analysis was evaluated on Rates of infection, disseminated intravascular coagulation (DIC) and death. An abnormal biphasic waveform on APTT analysis was shown to be useful in predicting a poor prognosis, often pre-empting infection, DIC, and death.
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