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April 1, 2006Clinical and Applied Thrombosis/HemostasisOpen Access

Frequency of Abnormal Biphasic aPTT Clot Waveforms in Patients with Underlying Disorders Associated with Disseminated Intravascular Coagulation

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Why the study?

Does the presence of an abnormal biphasic aPTT clot waveform associate with disseminated intravascular coagulation in hospitalized patients with elevated FDP levels?

Population

508 hospitalized patients with elevated fibrinogen degradation products (FDP) levels (>10 microg/mL)

Design

Cross-sectional

Authors

TMTakeshi MatsumotoSeirei Mikatabara General HospitalHWHideo WadaOsaka Institute of TechnologyYNYukiko NishiokaOkayama University Hospital

Discussion

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Implication

BPW's high specificity supports adjunctive DIC evaluation in elevated FDP; leaves open prospective validation before routine adoption.

Structured PICO

Does the presence of an abnormal biphasic aPTT clot waveform associate with disseminated intravascular coagulation in hospitalized patients with elevated FDP levels?

P
Population
508 hospitalized patients with elevated fibrinogen degradation products (FDP) levels (>10 microg/mL)
I
Intervention
Abnormal biphasic waveform (BPW) pattern on activated partial thromboplastin time (aPTT)
O
Outcome
Association of BPW with the diagnosis of disseminated intravascular coagulation (DIC) according to ISTH and JMHW criteriasurrogate

The abnormal biphasic aPTT waveform is a highly specific, though moderately sensitive, marker for disseminated intravascular coagulation in hospitalized patients, particularly those with infections.

Cite This Study

Matsumoto et al. (2006) studied this question.

synapsesocial.com/papers/6a7489f60081fe7b05dbdb45https://doi.org/10.1177/107602960601200206
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