Key result
The addition of nicardipine to enalapril significantly reduced blood pressure from baseline (P<0.05) in patients with inadequately controlled essential hypertension.
Why the study?
Does adding nicardipine to enalapril reduce blood pressure in patients with essential hypertension inadequately controlled on enalapril monotherapy?
Population
12 patients with essential hypertension and inadequate blood pressure control after 6 weeks of monotherapy…
Comparison
Nicardipine 30 mg three times daily added to… vs Placebo added to enalapril 20 mg daily for 2…
Design
RCT
Follow-up
2 weeks per treatment period
Authors
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Supports nicardipine add-on to enalapril for uncontrolled hypertension; extends RCT evidence for dual therapy in essential hypertension.
RCT (n=12)
Does adding nicardipine to enalapril reduce blood pressure in patients with essential hypertension inadequately controlled on enalapril monotherapy?
p-value: p=<0.05
The addition of nicardipine to enalapril provides an effective and well-tolerated antihypertensive combination for patients with inadequately controlled essential hypertension.
Donnelly et al. (1986) conducted an RCT in essential hypertension (n=12). Nicardipine vs. Placebo was evaluated on Blood pressure (p=<0.05). The addition of nicardipine to enalapril significantly reduced blood pressure from baseline (P<0.05) in patients with inadequately controlled essential hypertension.
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