What does this research mean for the field?

A novel HLA allele, HLA-B*52:139, exists and is characterized by a single nonsynonymous nucleotide substitution at nucleotide 365 of the HLA-B*52:01:01:01 allele. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

Characterize a novel variant of the HLA-B gene detected during human leukocyte antigen typing.

August 30, 2026HLAOpen Access

Discovery of the Novel HLA‐B*52:139 Allele in a Taiwanese Individual

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Authors

KYKuo-Liang Yang PLPy‐Yu Lin PLPy‐Yu Lin

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Overview

Genomic sequencing reveals a novel HLA-B*52:139 allele in a Taiwanese individual, highlighting genetic diversity in human leukocyte antigen loci.

Key Points

Characterize a novel variant of the HLA-B gene detected during human leukocyte antigen typing.
Sequenced human leukocyte antigen loci in a Taiwanese individual to characterize an uncataloged HLA-B allele.
Identified the novel allele HLA-B*52:139.
Characterized a single nonsynonymous nucleotide substitution at position 365 relative to HLA-B*52:01:01:01 that defines the novel sequence.

Cite This Study

Yang et al. (2026) studied this question.

synapsesocial.com/papers/6a93efe56c1a8fb52e79bf47 https://doi.org/10.1111/tan.70954

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August 30, 2026HLAOpen Access

Discovery of the Novel HLA‐B*52:139 Allele in a Taiwanese Individual

View Full Paper

Ask AI

Bookmark

Authors

KYKuo-Liang Yang PLPy‐Yu Lin PLPy‐Yu Lin

Discussion

Member takes

Overview

Genomic sequencing reveals a novel HLA-B*52:139 allele in a Taiwanese individual, highlighting genetic diversity in human leukocyte antigen loci.

Key Points

Characterize a novel variant of the HLA-B gene detected during human leukocyte antigen typing.
Sequenced human leukocyte antigen loci in a Taiwanese individual to characterize an uncataloged HLA-B allele.
Identified the novel allele HLA-B*52:139.
Characterized a single nonsynonymous nucleotide substitution at position 365 relative to HLA-B*52:01:01:01 that defines the novel sequence.

Cite This Study

Yang et al. (2026) studied this question.

synapsesocial.com/papers/6a93efe56c1a8fb52e79bf47 https://doi.org/10.1111/tan.70954

View Full Paper

Ask AI

Bookmark