Experimental study demonstrates efficient synthesis of butyrolactone derivatives using N-formylmorpholine, highlighting an affordable and clean green chemistry protocol.
The reaction between dimethyl acetylenedicarboxylate and various OH-acids in N-formylmorpholine leads to butyrolactone derivatives in nearly good yields. The present protocol offers the advantages of clean reaction, short reaction time, high yield, easy purification and affordability of the catalyst.
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IAU (2026) studied this question.
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