Laboratory study demonstrates efficient solvent-free synthesis of oxazole derivatives using N-formylmorpholine, highlighting a greener pathway for heterocyclic drug precursors.
An efficient synthesis of oxazoles, under solvent-free conditions, is described via reaction between ammonium thiocyanate, acid chlorides, and ethyl bromopyruvate or ethyl 2-chloroacetoacetate in the presence of N-formylmorpholine.
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IAU (2026) studied this question.
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