Synthesis of thiazolane derivatives in the presence of N-formylmorpholine

N-formylmorpholine accelerated synthesis of thiazolane derivatives by employing of three-component reactions of primary amines, dialkyl acetylenedicarboxylates and isothiocyanates under solvent-free conditions at room temperature in a good yield. The above synthetic procedure offers rapid access to novel and diversely substituted thiazolane derivatives.